Two new drugs, the first capable of slowing down the debilitating progression of Alzheimer’s disease, have become embroiled in one of the biggest medical controversies in recent years. For their defenders, the drugs lecanemab and donanemab represent the first real chance to fight the disease after decades of research — for detractors, they are another disappointment after a long line of costly failures. “We have turned a corner” thanks to these treatments, British biologist John Hardy, who has been studying Alzheimer’s since the 1990s, told AFP. Rob Howard, a professor of old age psychiatry at University College London, was on the other side. “I think that the drugs have been used to raise false and unrealistic hopes in people with Alzheimer’s disease and their families,” he said. These opposing statements sum up the entrenched positions on the recently introduced drugs for Alzheimer’s, the most common form of dementia which millions of people across the world suffer from. Lecanemab, sold under the name Leqembi, was developed by US pharma firms Biogen and Eisai. Donanemab, developed by pharma giant Eli Lilly, is sold as Kisunla. The controversy has seen countries take different stances on whether to approve the drugs or not. The United States gave the green light to lecanemab in 2023, then donanemab earlier this year. However the European Union rejected lecanemab in July, a bad omen for donanemab’s chance of approval. Last month, the UK steered a middle course, approving the use of lecanemab but not making it available on the state National Health Service. What no one denies is that the two drugs are the most effective Alzheimer’s treatments ever — but their effectiveness is limited. Both appear to reduce cognitive decline in patients at the onset of their disease by around 30 percent. While that may seem high, it represents a relatively small difference over the year-and-a-half period when the studies were carried out. “The benefits are so tiny as to be practically invisible in an individual patient,” Howard said. – Exorbitant cost – For critics, there are not enough benefits to outweigh the risks of the drugs, which can sometimes cause brain swelling or bleeding that in rare cases has proved fatal. And they are very expensive. At the prices being charged by Biogen and Eisai in the United States, lecanemab would cost 133 billion euros ($148 billion) if given to all eligible patients in the EU, according to a 2023 study. Advocates of the drugs, including many neurologists, believe they can offer patients a few more precious months of autonomy. They also believe that the effectiveness of the drugs could be multiplied if patients started taking them earlier in the disease’s progression. This could soon be more practicable as research on diagnosing Alzheimer’s more quickly has recently been making significant strides. The differing national policies could also mean that poorer patients are left behind. “We will see rich people going to the US” for the drugs, Hardy said. The debate can be traced back in part to a seminal 1992 article by Hardy about how the disease actually works. The article argues that clumps of protein called amyloid plaques — a constant in the brains of Alzheimer’s patients — are not just one element among others, but the main factor triggering the disease. Over the decades, many drugs targeting these amyloid plaques were developed, all of which failed — until lecanemab and donanemab. Pressure from families The scepticism from some quarters about the new drugs could be because the previous ones were defended and even lauded by some, despite their ineffectiveness.