“It has a lot of potential,” said Dr. Beatrice Chen, a family planning specialist at the University of Pittsburgh, who wasn´t involved in the new research. “Birth control is not one-size-fits-all,” and women need more options.
Today, women who want the convenience of long-lasting contraception can choose among various devices, from a weekly patch to a monthly vaginal ring to an IUD that lasts for years.
It wasn´t clear that “the Pill” – one of the most popular forms of birth control because it´s cheap and easy to use – ever could join that list. Pills of all sorts generally pass through the body in a day.
A team from the lab of Massachusetts Institute of Technology inventor Robert Langer engineered a fix to protect pills from the harsh environment of the digestive system.
“We developed this capsule system that looks like a starfish, that can stay in the stomach several days, weeks, even a month at a time,” said Dr. Giovanni Traverso of Boston´s Brigham and Women´s Hospital, a senior author of the study.
The star-shaped device has six arms, and each holds a certain medication dose. The device is folded inside an ordinary-sized capsule. Swallow the capsule and stomach acid dissolves the coating, letting the star unfold. It´s too big to fit through the stomach´s exit but not big enough to cause an obstruction. As medication dissolves out of each of the arms, the device breaks down until it can safely pass through the digestive system.
Langer and Traverso´s team first used the technology to try turning daily drugs for malaria and HIV into capsules that lasted a week or two. They also are experimental, but longer-lasting pills one day could help patients with serious diseases better stick with treatment. A logical next attempt: A month-long oral contraceptive. First, they had to tweak the star-shaped device. They made it stronger and turned to long-lasting contraceptive implants for the materials to hold the hormone ingredient and let it gradually seep out.
Then they tested the contraceptive capsules in pigs, which have human-like digestive systems. The experimental capsules released the contraceptive fairly consistently for up to four weeks, and the amount in the pigs´ bloodstream was similar to what daily tablets deliver, MIT lead authors Ameya Kirtane and Tiffany Hua reported in the journal Science Translational Medicine.
Lyndra Therapeutics Inc., a Massachusetts company co-founded by Langer and Traverso, is further developing the monthly pill and multiple other uses for the technology.
To be most useful, the capsule should be designed to emit three weeks of contraception and then allow for a woman’s period, like a month’s supply of birth control pills does, Traverso said. That would alert women when it was time to take another monthly dose.
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