Daily Times

New research showcases an innovative method of delivering vaccines straight to our white blood cells, strengthening the immune system against cancer and serious infections.

Immunotherapy, which is a widely used form of treatment against cancer, boosts the body’s immune system in the fight against tumors.

Be it checkpoint inhibitor drugs or adoptive cell transfer, immunotherapy works primarily with T cells, which are a type of white blood cell, or lymphocyte.

Largely, our immune systems rely on B lymphocytes and T lymphocytes.

The former are active in a variety of infections, whereas the latter must be activated when combating cancer or more serious infections such as tuberculosis.

But T cells are more difficult to trigger than B lymphocytes. To activate T cells, healthcare providers must inject a peptide that often deteriorates before reaching its destination.

But now, an international team of researchers from different universities across Europe has devised a type of resilient microcapsule that can help to deliver vaccines straight to the core of T cells.

The scientists created these microcapsules using an unconventional material: synthetic spider silk.

The research was led by Prof. Carole Bourquin, who is a specialist in cancer immunotherapy at the faculties of medicine and science of the University of Geneva in Switzerland.

She says, “To develop immunotherapeutic drugs effective against cancer, it is essential to generate a significant response of T lymphocytes. As the current vaccines have only limited action on T cells, it is crucial to develop other vaccination procedures to overcome this issue.”

The findings were published in the journal Biomaterials.

Prof. Bourquin and her team used synthetic biopolymers based on the silk spun by spiders. Spider silk is an incredibly strong and resilient material. In fact, it is thought to be “five times stronger than steel of the same diameter.”

Study co-author Thomas Scheibel, who’s an expert on spider silk from the University of Bayreuth in Germany, explains the procedure used by the scientists. “We recreated this special silk in the lab to insert a peptide with vaccine properties,” he says.

Published in Daily Times, June 15^th 2018.