MIAMI: Top-seeded Daniil Medvedev crashed out of the Miami Open Wednesday on a day of upsets that also saw Australian Open champion Naomi Osaka ousted from the quarter-finals. Seventh-seeded Spaniard Roberto Bautista Agut beat Medvedev 6-4, 6-2, for his third win in as many meetings with the Russian who was runner-up to Novak Djokovic at the Australian Open and ascended to No. 2 in the world with his victory at Marseille in March. Women’s world No. 2 Osaka — seeded second behind top-ranked Ashleigh Barty in the prestigious ATP Masters and WTA hardcourt tournament — had bowed out hours earlier, the Japanese star’s 23-match winning streak coming to a crashing halt with a 6-0, 6-4 loss to Greece’s Maria Sakkari. Bautista booked a semi-final showdown with 19-year-old Italian Jannick Sinner, the world No. 31 who beat Kazakhstan’s Alexander Bublik 7-6 (7/5), 6-4. Sakkari will face eighth-seeded Canadian Bianca Andreescu for a place in the women’s final. Andreescu, ranked ninth in the world, clawed out a 6-4, 3-6, 6-3 victory over tenacious 58th-ranked Spaniard Sara Sorribes Tormo. Osaka, playing her first tournament since lifting her fourth Grand Slam title at the Australian Open, won just eight points in the first set as she failed to muster a single winner. Osaka broke in the second game of the second set and seized a 3-0 lead before Sakkari roared back for a victory that ended Osaka’s chance of overtaking Australia’s Barty –– who had already booked her semi-final spot –– atop the world rankings this week. Osaka acknowledged that the rankings race may have affected her against Greece’s 25th-ranked Sakkari. Osaka hadn’t dropped a set at love since her last defeat, which came in February 2020 in a Fed Cup match. Andreescu, the 2019 US Open champion trying to work her way back this year after a 15-month injury absence, broke Sorribes in the final game of the opening set, launching a run of eight straight service breaks. Andreescu was irked by a time violation early in the second set, in which Sorribes held serve for the only time in the set for a 5-3 lead –– enough of an edge to level the match. Up a break at 3-2 in the third, Andreescu saved three break points to hold, broke Sorribes again only to drop her own serve but finally sealed it with a stinging backhand down the line on her second match point. The Spaniard gained the first break of a tense opening set for a 5-4 lead, then saved a break point to pocket the set on his second opportunity. He broke Medvedev to open the second set, and the Russian never found a way back in, unable to convert two break points before dropping his serve again to trail 4-1. Bautista served out the match in no-nonsense style, with a love game after one hour and 32 minutes. Against Sinner, he’ll be looking to avenge a three-set defeat in the third round at Dubai. Sinner handled everything Bublik could throw at him on Wednesday –– from a 105mph forehand return to an underhand serve. In the end the Italian’s 28 forehand winners were plenty to book a semi-final berth in just his third Masters 1000 appearance.